Trehalose-Induced Activation of Autophagy Improves Cardiac Remodeling After Myocardial Infarction.
Identifieur interne : 000C09 ( Main/Exploration ); précédent : 000C08; suivant : 000C10Trehalose-Induced Activation of Autophagy Improves Cardiac Remodeling After Myocardial Infarction.
Auteurs : Sebastiano Sciarretta [Italie] ; Derek Yee [États-Unis] ; Narayani Nagarajan [États-Unis] ; Franca Bianchi [Italie] ; Toshiro Saito [États-Unis] ; Valentina Valenti [Italie] ; Mingming Tong [États-Unis] ; Dominic P. Del Re [États-Unis] ; Carmine Vecchione [Italie] ; Leonardo Schirone [Italie] ; Maurizio Forte [Italie] ; Speranza Rubattu [Italie] ; Akihiro Shirakabe [États-Unis] ; V Subbarao Boppana [États-Unis] ; Massimo Volpe [Italie] ; Giacomo Frati [Italie] ; Peiyong Zhai [États-Unis] ; Junichi Sadoshima [États-Unis]Source :
- Journal of the American College of Cardiology [ 1558-3597 ] ; 2018.
Descripteurs français
- KwdFr :
- Animaux, Animaux nouveau-nés, Autophagie (), Cellules cultivées, Coeur (), Facteurs de transcription à motifs basiques hélice-boucle-hélice et à glissière à leucines (métabolisme), Infarctus du myocarde (traitement médicamenteux), Modèles animaux de maladie humaine, Rats, Remodelage ventriculaire (), Souris transgéniques, Tréhalose (usage thérapeutique), Évaluation préclinique de médicament.
- MESH :
- métabolisme : Facteurs de transcription à motifs basiques hélice-boucle-hélice et à glissière à leucines.
- traitement médicamenteux : Infarctus du myocarde.
- usage thérapeutique : Tréhalose.
- Animaux, Animaux nouveau-nés, Autophagie, Cellules cultivées, Coeur, Modèles animaux de maladie humaine, Rats, Remodelage ventriculaire, Souris transgéniques, Évaluation préclinique de médicament.
English descriptors
- KwdEn :
- Animals, Animals, Newborn, Autophagy (drug effects), Basic Helix-Loop-Helix Leucine Zipper Transcription Factors (metabolism), Cells, Cultured, Disease Models, Animal, Drug Evaluation, Preclinical, Heart (drug effects), Mice, Transgenic, Myocardial Infarction (drug therapy), Rats, Trehalose (therapeutic use), Ventricular Remodeling (drug effects).
- MESH :
- chemical , metabolism : Basic Helix-Loop-Helix Leucine Zipper Transcription Factors.
- drug effects : Autophagy, Heart, Ventricular Remodeling.
- drug therapy : Myocardial Infarction.
- chemical , therapeutic use : Trehalose.
- Animals, Animals, Newborn, Cells, Cultured, Disease Models, Animal, Drug Evaluation, Preclinical, Mice, Transgenic, Rats.
Abstract
Trehalose (TRE) is a natural, nonreducing disaccharide synthesized by lower organisms. TRE exhibits an extraordinary ability to protect cells against different kinds of stresses through activation of autophagy. However, the effect of TRE on the heart during stress has never been tested.
DOI: 10.1016/j.jacc.2018.02.066
PubMed: 29724354
Affiliations:
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Le document en format XML
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Del Re</name><affiliation wicri:level="2"><nlm:affiliation>Department of Cell Biology and Molecular Medicine, Rutgers New Jersey Medical School, Newark, New Jersey.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">New Jersey</region></placeName><wicri:cityArea>Department of Cell Biology and Molecular Medicine, Rutgers New Jersey Medical School, Newark</wicri:cityArea></affiliation></author><author><name sortKey="Vecchione, Carmine" sort="Vecchione, Carmine" uniqKey="Vecchione C" first="Carmine" last="Vecchione">Carmine Vecchione</name><affiliation wicri:level="1"><nlm:affiliation>Department of AngioCardioNeurology, IRCCS Neuromed, Pozzilli, Italy; University of Salerno, Medicine and Surgery, Baronissi, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of AngioCardioNeurology, IRCCS Neuromed, Pozzilli, Italy; University of Salerno, Medicine and Surgery, Baronissi</wicri:regionArea><wicri:noRegion>Baronissi</wicri:noRegion></affiliation></author><author><name sortKey="Schirone, Leonardo" sort="Schirone, Leonardo" uniqKey="Schirone L" first="Leonardo" last="Schirone">Leonardo Schirone</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina</wicri:regionArea><wicri:noRegion>Latina</wicri:noRegion></affiliation></author><author><name sortKey="Forte, Maurizio" sort="Forte, Maurizio" uniqKey="Forte M" first="Maurizio" last="Forte">Maurizio Forte</name><affiliation wicri:level="1"><nlm:affiliation>Department of AngioCardioNeurology, IRCCS Neuromed, Pozzilli, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of AngioCardioNeurology, IRCCS Neuromed, Pozzilli</wicri:regionArea><wicri:noRegion>Pozzilli</wicri:noRegion></affiliation></author><author><name sortKey="Rubattu, Speranza" sort="Rubattu, Speranza" uniqKey="Rubattu S" first="Speranza" last="Rubattu">Speranza Rubattu</name><affiliation wicri:level="3"><nlm:affiliation>Department of AngioCardioNeurology, IRCCS Neuromed, Pozzilli, Italy; Department of Clinical and Molecular Medicine, Sapienza University of Rome, Rome, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of AngioCardioNeurology, IRCCS Neuromed, Pozzilli, Italy; Department of Clinical and Molecular Medicine, Sapienza University of Rome, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Shirakabe, Akihiro" sort="Shirakabe, Akihiro" uniqKey="Shirakabe A" first="Akihiro" last="Shirakabe">Akihiro Shirakabe</name><affiliation wicri:level="2"><nlm:affiliation>Department of Cell Biology and Molecular Medicine, Rutgers New Jersey Medical School, Newark, New Jersey.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">New Jersey</region></placeName><wicri:cityArea>Department of Cell Biology and Molecular Medicine, Rutgers New Jersey Medical School, Newark</wicri:cityArea></affiliation></author><author><name sortKey="Boppana, V Subbarao" sort="Boppana, V Subbarao" uniqKey="Boppana V" first="V Subbarao" last="Boppana">V Subbarao Boppana</name><affiliation wicri:level="2"><nlm:affiliation>Department of Cell Biology and Molecular Medicine, Rutgers New Jersey Medical School, Newark, New Jersey.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">New Jersey</region></placeName><wicri:cityArea>Department of Cell Biology and Molecular Medicine, Rutgers New Jersey Medical School, Newark</wicri:cityArea></affiliation></author><author><name sortKey="Volpe, Massimo" sort="Volpe, Massimo" uniqKey="Volpe M" first="Massimo" last="Volpe">Massimo Volpe</name><affiliation wicri:level="3"><nlm:affiliation>Department of AngioCardioNeurology, IRCCS Neuromed, Pozzilli, Italy; Department of Clinical and Molecular Medicine, Sapienza University of Rome, Rome, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of AngioCardioNeurology, IRCCS Neuromed, Pozzilli, Italy; Department of Clinical and Molecular Medicine, Sapienza University of Rome, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Frati, Giacomo" sort="Frati, Giacomo" uniqKey="Frati G" first="Giacomo" last="Frati">Giacomo Frati</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy; Department of AngioCardioNeurology, IRCCS Neuromed, Pozzilli, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy; Department of AngioCardioNeurology, IRCCS Neuromed, Pozzilli</wicri:regionArea><wicri:noRegion>Pozzilli</wicri:noRegion></affiliation></author><author><name sortKey="Zhai, Peiyong" sort="Zhai, Peiyong" uniqKey="Zhai P" first="Peiyong" last="Zhai">Peiyong Zhai</name><affiliation wicri:level="2"><nlm:affiliation>Department of Cell Biology and Molecular Medicine, Rutgers New Jersey Medical School, Newark, New Jersey.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">New Jersey</region></placeName><wicri:cityArea>Department of Cell Biology and Molecular Medicine, Rutgers New Jersey Medical School, Newark</wicri:cityArea></affiliation></author><author><name sortKey="Sadoshima, Junichi" sort="Sadoshima, Junichi" uniqKey="Sadoshima J" first="Junichi" last="Sadoshima">Junichi Sadoshima</name><affiliation wicri:level="2"><nlm:affiliation>Department of Cell Biology and Molecular Medicine, Rutgers New Jersey Medical School, Newark, New Jersey. Electronic address: sadoshju@njms.rutgers.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">New Jersey</region></placeName><wicri:cityArea>Department of Cell Biology and Molecular Medicine, Rutgers New Jersey Medical School, Newark</wicri:cityArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2018">2018</date><idno type="RBID">pubmed:29724354</idno><idno type="pmid">29724354</idno><idno type="doi">10.1016/j.jacc.2018.02.066</idno><idno type="wicri:Area/PubMed/Corpus">000111</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000111</idno><idno type="wicri:Area/PubMed/Curation">000111</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000111</idno><idno type="wicri:Area/PubMed/Checkpoint">000082</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000082</idno><idno type="wicri:Area/Ncbi/Merge">000442</idno><idno type="wicri:Area/Ncbi/Curation">000442</idno><idno type="wicri:Area/Ncbi/Checkpoint">000442</idno><idno type="wicri:Area/Main/Merge">000C09</idno><idno type="wicri:Area/Main/Curation">000C09</idno><idno type="wicri:Area/Main/Exploration">000C09</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Trehalose-Induced Activation of Autophagy Improves Cardiac Remodeling After Myocardial Infarction.</title><author><name sortKey="Sciarretta, Sebastiano" sort="Sciarretta, Sebastiano" uniqKey="Sciarretta S" first="Sebastiano" last="Sciarretta">Sebastiano Sciarretta</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy; Department of AngioCardioNeurology, IRCCS Neuromed, Pozzilli, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy; Department of AngioCardioNeurology, IRCCS Neuromed, Pozzilli</wicri:regionArea><wicri:noRegion>Pozzilli</wicri:noRegion></affiliation></author><author><name sortKey="Yee, Derek" sort="Yee, Derek" uniqKey="Yee D" first="Derek" last="Yee">Derek Yee</name><affiliation wicri:level="2"><nlm:affiliation>Department of Cell Biology and Molecular Medicine, Rutgers New Jersey Medical School, Newark, New Jersey.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">New Jersey</region></placeName><wicri:cityArea>Department of Cell Biology and Molecular Medicine, Rutgers New Jersey Medical School, Newark</wicri:cityArea></affiliation></author><author><name sortKey="Nagarajan, Narayani" sort="Nagarajan, Narayani" uniqKey="Nagarajan N" first="Narayani" last="Nagarajan">Narayani Nagarajan</name><affiliation wicri:level="2"><nlm:affiliation>Department of Cell Biology and Molecular Medicine, Rutgers New Jersey Medical School, Newark, New Jersey.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">New Jersey</region></placeName><wicri:cityArea>Department of Cell Biology and Molecular Medicine, Rutgers New Jersey Medical School, Newark</wicri:cityArea></affiliation></author><author><name sortKey="Bianchi, Franca" sort="Bianchi, Franca" uniqKey="Bianchi F" first="Franca" last="Bianchi">Franca Bianchi</name><affiliation wicri:level="1"><nlm:affiliation>Department of AngioCardioNeurology, IRCCS Neuromed, Pozzilli, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of AngioCardioNeurology, IRCCS Neuromed, Pozzilli</wicri:regionArea><wicri:noRegion>Pozzilli</wicri:noRegion></affiliation></author><author><name sortKey="Saito, Toshiro" sort="Saito, Toshiro" uniqKey="Saito T" first="Toshiro" last="Saito">Toshiro Saito</name><affiliation wicri:level="2"><nlm:affiliation>Department of Cell Biology and Molecular Medicine, Rutgers New Jersey Medical School, Newark, New Jersey.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">New Jersey</region></placeName><wicri:cityArea>Department of Cell Biology and Molecular Medicine, Rutgers New Jersey Medical School, Newark</wicri:cityArea></affiliation></author><author><name sortKey="Valenti, Valentina" sort="Valenti, Valentina" uniqKey="Valenti V" first="Valentina" last="Valenti">Valentina Valenti</name><affiliation wicri:level="3"><nlm:affiliation>Department of Imaging, Bambino Gesù Children Hospital, IRCCS, Rome, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Imaging, Bambino Gesù Children Hospital, IRCCS, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Tong, Mingming" sort="Tong, Mingming" uniqKey="Tong M" first="Mingming" last="Tong">Mingming Tong</name><affiliation wicri:level="2"><nlm:affiliation>Department of Cell Biology and Molecular Medicine, Rutgers New Jersey Medical School, Newark, New Jersey.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">New Jersey</region></placeName><wicri:cityArea>Department of Cell Biology and Molecular Medicine, Rutgers New Jersey Medical School, Newark</wicri:cityArea></affiliation></author><author><name sortKey="Del Re, Dominic P" sort="Del Re, Dominic P" uniqKey="Del Re D" first="Dominic P" last="Del Re">Dominic P. Del Re</name><affiliation wicri:level="2"><nlm:affiliation>Department of Cell Biology and Molecular Medicine, Rutgers New Jersey Medical School, Newark, New Jersey.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">New Jersey</region></placeName><wicri:cityArea>Department of Cell Biology and Molecular Medicine, Rutgers New Jersey Medical School, Newark</wicri:cityArea></affiliation></author><author><name sortKey="Vecchione, Carmine" sort="Vecchione, Carmine" uniqKey="Vecchione C" first="Carmine" last="Vecchione">Carmine Vecchione</name><affiliation wicri:level="1"><nlm:affiliation>Department of AngioCardioNeurology, IRCCS Neuromed, Pozzilli, Italy; University of Salerno, Medicine and Surgery, Baronissi, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of AngioCardioNeurology, IRCCS Neuromed, Pozzilli, Italy; University of Salerno, Medicine and Surgery, Baronissi</wicri:regionArea><wicri:noRegion>Baronissi</wicri:noRegion></affiliation></author><author><name sortKey="Schirone, Leonardo" sort="Schirone, Leonardo" uniqKey="Schirone L" first="Leonardo" last="Schirone">Leonardo Schirone</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina</wicri:regionArea><wicri:noRegion>Latina</wicri:noRegion></affiliation></author><author><name sortKey="Forte, Maurizio" sort="Forte, Maurizio" uniqKey="Forte M" first="Maurizio" last="Forte">Maurizio Forte</name><affiliation wicri:level="1"><nlm:affiliation>Department of AngioCardioNeurology, IRCCS Neuromed, Pozzilli, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of AngioCardioNeurology, IRCCS Neuromed, Pozzilli</wicri:regionArea><wicri:noRegion>Pozzilli</wicri:noRegion></affiliation></author><author><name sortKey="Rubattu, Speranza" sort="Rubattu, Speranza" uniqKey="Rubattu S" first="Speranza" last="Rubattu">Speranza Rubattu</name><affiliation wicri:level="3"><nlm:affiliation>Department of AngioCardioNeurology, IRCCS Neuromed, Pozzilli, Italy; Department of Clinical and Molecular Medicine, Sapienza University of Rome, Rome, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of AngioCardioNeurology, IRCCS Neuromed, Pozzilli, Italy; Department of Clinical and Molecular Medicine, Sapienza University of Rome, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Shirakabe, Akihiro" sort="Shirakabe, Akihiro" uniqKey="Shirakabe A" first="Akihiro" last="Shirakabe">Akihiro Shirakabe</name><affiliation wicri:level="2"><nlm:affiliation>Department of Cell Biology and Molecular Medicine, Rutgers New Jersey Medical School, Newark, New Jersey.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">New Jersey</region></placeName><wicri:cityArea>Department of Cell Biology and Molecular Medicine, Rutgers New Jersey Medical School, Newark</wicri:cityArea></affiliation></author><author><name sortKey="Boppana, V Subbarao" sort="Boppana, V Subbarao" uniqKey="Boppana V" first="V Subbarao" last="Boppana">V Subbarao Boppana</name><affiliation wicri:level="2"><nlm:affiliation>Department of Cell Biology and Molecular Medicine, Rutgers New Jersey Medical School, Newark, New Jersey.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">New Jersey</region></placeName><wicri:cityArea>Department of Cell Biology and Molecular Medicine, Rutgers New Jersey Medical School, Newark</wicri:cityArea></affiliation></author><author><name sortKey="Volpe, Massimo" sort="Volpe, Massimo" uniqKey="Volpe M" first="Massimo" last="Volpe">Massimo Volpe</name><affiliation wicri:level="3"><nlm:affiliation>Department of AngioCardioNeurology, IRCCS Neuromed, Pozzilli, Italy; Department of Clinical and Molecular Medicine, Sapienza University of Rome, Rome, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of AngioCardioNeurology, IRCCS Neuromed, Pozzilli, Italy; Department of Clinical and Molecular Medicine, Sapienza University of Rome, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Frati, Giacomo" sort="Frati, Giacomo" uniqKey="Frati G" first="Giacomo" last="Frati">Giacomo Frati</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy; Department of AngioCardioNeurology, IRCCS Neuromed, Pozzilli, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy; Department of AngioCardioNeurology, IRCCS Neuromed, Pozzilli</wicri:regionArea><wicri:noRegion>Pozzilli</wicri:noRegion></affiliation></author><author><name sortKey="Zhai, Peiyong" sort="Zhai, Peiyong" uniqKey="Zhai P" first="Peiyong" last="Zhai">Peiyong Zhai</name><affiliation wicri:level="2"><nlm:affiliation>Department of Cell Biology and Molecular Medicine, Rutgers New Jersey Medical School, Newark, New Jersey.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">New Jersey</region></placeName><wicri:cityArea>Department of Cell Biology and Molecular Medicine, Rutgers New Jersey Medical School, Newark</wicri:cityArea></affiliation></author><author><name sortKey="Sadoshima, Junichi" sort="Sadoshima, Junichi" uniqKey="Sadoshima J" first="Junichi" last="Sadoshima">Junichi Sadoshima</name><affiliation wicri:level="2"><nlm:affiliation>Department of Cell Biology and Molecular Medicine, Rutgers New Jersey Medical School, Newark, New Jersey. Electronic address: sadoshju@njms.rutgers.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">New Jersey</region></placeName><wicri:cityArea>Department of Cell Biology and Molecular Medicine, Rutgers New Jersey Medical School, Newark</wicri:cityArea></affiliation></author></analytic><series><title level="j">Journal of the American College of Cardiology</title><idno type="eISSN">1558-3597</idno><imprint><date when="2018" type="published">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Animals, Newborn</term><term>Autophagy (drug effects)</term><term>Basic Helix-Loop-Helix Leucine Zipper Transcription Factors (metabolism)</term><term>Cells, Cultured</term><term>Disease Models, Animal</term><term>Drug Evaluation, Preclinical</term><term>Heart (drug effects)</term><term>Mice, Transgenic</term><term>Myocardial Infarction (drug therapy)</term><term>Rats</term><term>Trehalose (therapeutic use)</term><term>Ventricular Remodeling (drug effects)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Animaux nouveau-nés</term><term>Autophagie ()</term><term>Cellules cultivées</term><term>Coeur ()</term><term>Facteurs de transcription à motifs basiques hélice-boucle-hélice et à glissière à leucines (métabolisme)</term><term>Infarctus du myocarde (traitement médicamenteux)</term><term>Modèles animaux de maladie humaine</term><term>Rats</term><term>Remodelage ventriculaire ()</term><term>Souris transgéniques</term><term>Tréhalose (usage thérapeutique)</term><term>Évaluation préclinique de médicament</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Basic Helix-Loop-Helix Leucine Zipper Transcription Factors</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Autophagy</term><term>Heart</term><term>Ventricular Remodeling</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Myocardial Infarction</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Facteurs de transcription à motifs basiques hélice-boucle-hélice et à glissière à leucines</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Trehalose</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Infarctus du myocarde</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Tréhalose</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Animals, Newborn</term><term>Cells, Cultured</term><term>Disease Models, Animal</term><term>Drug Evaluation, Preclinical</term><term>Mice, Transgenic</term><term>Rats</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Animaux nouveau-nés</term><term>Autophagie</term><term>Cellules cultivées</term><term>Coeur</term><term>Modèles animaux de maladie humaine</term><term>Rats</term><term>Remodelage ventriculaire</term><term>Souris transgéniques</term><term>Évaluation préclinique de médicament</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Trehalose (TRE) is a natural, nonreducing disaccharide synthesized by lower organisms. TRE exhibits an extraordinary ability to protect cells against different kinds of stresses through activation of autophagy. However, the effect of TRE on the heart during stress has never been tested.</div></front></TEI><affiliations><list><country><li>Italie</li><li>États-Unis</li></country><region><li>Latium</li><li>New Jersey</li></region><settlement><li>Rome</li></settlement></list><tree><country name="Italie"><noRegion><name sortKey="Sciarretta, Sebastiano" sort="Sciarretta, Sebastiano" uniqKey="Sciarretta S" first="Sebastiano" last="Sciarretta">Sebastiano Sciarretta</name></noRegion><name sortKey="Bianchi, Franca" sort="Bianchi, Franca" uniqKey="Bianchi F" first="Franca" last="Bianchi">Franca Bianchi</name><name sortKey="Forte, Maurizio" sort="Forte, Maurizio" uniqKey="Forte M" first="Maurizio" last="Forte">Maurizio Forte</name><name sortKey="Frati, Giacomo" sort="Frati, Giacomo" uniqKey="Frati G" first="Giacomo" last="Frati">Giacomo Frati</name><name sortKey="Rubattu, Speranza" sort="Rubattu, Speranza" uniqKey="Rubattu S" first="Speranza" last="Rubattu">Speranza Rubattu</name><name sortKey="Schirone, Leonardo" sort="Schirone, Leonardo" uniqKey="Schirone L" first="Leonardo" last="Schirone">Leonardo Schirone</name><name sortKey="Valenti, Valentina" sort="Valenti, Valentina" uniqKey="Valenti V" first="Valentina" last="Valenti">Valentina Valenti</name><name sortKey="Vecchione, Carmine" sort="Vecchione, Carmine" uniqKey="Vecchione C" first="Carmine" last="Vecchione">Carmine Vecchione</name><name sortKey="Volpe, Massimo" sort="Volpe, Massimo" uniqKey="Volpe M" first="Massimo" last="Volpe">Massimo Volpe</name></country><country name="États-Unis"><region name="New Jersey"><name sortKey="Yee, Derek" sort="Yee, Derek" uniqKey="Yee D" first="Derek" last="Yee">Derek Yee</name></region><name sortKey="Boppana, V Subbarao" sort="Boppana, V Subbarao" uniqKey="Boppana V" first="V Subbarao" last="Boppana">V Subbarao Boppana</name><name sortKey="Del Re, Dominic P" sort="Del Re, Dominic P" uniqKey="Del Re D" first="Dominic P" last="Del Re">Dominic P. Del Re</name><name sortKey="Nagarajan, Narayani" sort="Nagarajan, Narayani" uniqKey="Nagarajan N" first="Narayani" last="Nagarajan">Narayani Nagarajan</name><name sortKey="Sadoshima, Junichi" sort="Sadoshima, Junichi" uniqKey="Sadoshima J" first="Junichi" last="Sadoshima">Junichi Sadoshima</name><name sortKey="Saito, Toshiro" sort="Saito, Toshiro" uniqKey="Saito T" first="Toshiro" last="Saito">Toshiro Saito</name><name sortKey="Shirakabe, Akihiro" sort="Shirakabe, Akihiro" uniqKey="Shirakabe A" first="Akihiro" last="Shirakabe">Akihiro Shirakabe</name><name sortKey="Tong, Mingming" sort="Tong, Mingming" uniqKey="Tong M" first="Mingming" last="Tong">Mingming Tong</name><name sortKey="Zhai, Peiyong" sort="Zhai, Peiyong" uniqKey="Zhai P" first="Peiyong" last="Zhai">Peiyong Zhai</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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